Hi Friends,
As we recognize Breast Cancer Awareness Month this OctoberĀ 
, letās talk about an important but often overlooked factor in breast cancer: theĀ estrobolome. This special part of our gut microbiome is responsible for metabolizing estrogens, playing a critical role in hormonal balance!
Sadly, breast cancer affects 1 in 8 women in the U.S., with Estrogen-Receptor Positive (ER+) cancer being the most common type. In ER+ cases, estrogens arenāt properly metabolized and can drive cancer growth.
How Estrogen Detoxification Works:
1.Ā Liver Detox (Phase 1 & 2)
Estrogens are first processed by the liver through two detox phases, which convert them into conjugated estrogens ready for excretion.Ā MagnesiumĀ plays a vital role in Phase 2, not only supporting estrogen detox but also promoting regular bowel movements, another key way we eliminate estrogens from the body.
2.Ā Bile Secretion & Gut Health (Phase 3)
The gallbladder releases bile containing conjugated estrogens into the small intestine, where ourĀ estrobolomeĀ takes over. This part of the gut microbiome produces an enzyme calledĀ beta-glucuronidase, which canĀ de-conjugateĀ estrogens, sending them back into circulationĀ 
.
The Impact of Beta-Glucuronidase on Breast Cancer
Women with ER+ breast cancer often show high levels ofĀ beta-glucuronidaseĀ in their gut microbiome due to an overgrowth of bad bacteria, a condition known asĀ Dysbiosis. This enzyme enables the recycling of estrogens, which may contribute to the growth of ER+ cancers.
Supporting Healthy Estrogen Metabolism Naturally:
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Calcium-D-GlucarateĀ helps blockĀ
Ā the activity of beta-glucuronidase, preventing estrogen recycling and promoting healthier hormone balance. - Estrogen BalancerĀ is a potent supplement containingĀ I3CĀ andĀ DIM, compounds found in cruciferous veggies like broccoliĀ
. These promote Phase 1 liver detoxification and help shift estrogen metabolism toward healthier "clean" estrogens while reducing harmful ādirtyā estrogens. I like to call it the "broccoli pill" for its powerful benefits! - Optimize YourĀ Vitamin D: Maintaining a vitamin D level between 60-80 ng/mL is a simple but powerful way toĀ support breast cancer prevention.Ā
- TakeĀ Essential MagnesiumĀ at bedtime. Not only will this improve your sleep quality, it will also facilitate your liver's metabolism of estrogens and promote healthy bowel regularity.
- Clean up the dysbiosis in your gut microbiome with herbal antimicrobials likeĀ Berberine ProĀ andĀ Oregano Oil. These herbs can kill the "bad" bacteria in the gut that are producing the high levels of beta-glucuronidase which is recycling the estrogens.
- Avoid alcohol, which slows the liver's metabolism of estrogens.Ā Women who drink alcohol regularlyĀ have a higher risk of breast cancer.
For a deeper dive into estrogen metabolism and how it impacts your health, please watch my video onĀ Estrogen Dominance.
Ā is a cruciferous vegetable that hasĀ sulforaphane,Ā which hasĀ anti-cancer properties.Ā Itās also a rich source ofĀ diindolylmethane (DIM), which hasĀ estrogen-metabolizing properties.Ā
Warm regards,
